血生化检测尿酸偏高,RS2231142位点是杂合子
今天去做了血生化检测,尿酸588.6umol/L,参考正常范围是202-428。明显的升高。
根据NG 2013年的GWAS结果,RS2231142位点跟尿酸水平高低的相关性的P值是1*10^-134,异常显著的一个位点。很不幸,我的这个位点是个杂合子。
WeGene上有没有这个位点也是杂合子或者突变纯合子的?尿酸检查结果如何?
根据NG 2013年的GWAS结果,RS2231142位点跟尿酸水平高低的相关性的P值是1*10^-134,异常显著的一个位点。很不幸,我的这个位点是个杂合子。
WeGene上有没有这个位点也是杂合子或者突变纯合子的?尿酸检查结果如何?
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http://www.snpedia.com/index.php/Gout
Gout is a disease caused by a build-up of uric acid in the joints, provoking an arthritis-like inflammatory response. Wikipedia SNPs in several genes have been found in independent studies to be associated with increased risk of gout.
ABCG2
rs2231142 causes ~10% of gout
[rs72552713]], risk allele A in SNPedia orientation [PMID 25646370 ]
PRKG2 was associated with gout in a Taiwanese study [PMID 18678579]
rs7688672
rs6837293
SLC2A9
rs16890979, risk allele C in the Amish and Framingham/Rotterdam studies [PMID 18834626]
rs1014290, risk allele A
rs6449213; the C allele appears to be protective against gout [PMID 18327257]
rs6855911 [PMID 18398472]
rs737267 [PMID 18398472]
rs12498742, minor G allele reduces risk for gout [PMID 23263486]
rs3775948, risk allele G [PMID 25646370 ]
SLC17A3
rs1165205; the T allele appears to be protective against gout in the Framingham/Rotterdam study [PMID 18834626]. Note that 23andMe reports this as the A allele.
An intergenic SNP on chromosome 4, rs10489070, was associated with gout in both the Amish and Framingham/Rotterdam studies.
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楼主刚才提到的那个abcg2上的 我是aa纯合 从小尿酸就上600 这事儿我会乱说么。。。
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BMI已经快接近正常偏胖了
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